The handbook focus mostly on the scientific foundations and engineering techniques - while also addressing the proper integration of policies and access control mechanisms, for example, how human-developed policies can be properly enforced by an automated system. - Addresses the technical challenges facing design of secure infrastructures by providing examples of problems and solutions from a wide variety of internal and external attack scenarios - Includes contributions from leading researchers and practitioners in relevant application areas such as smart power grid, intelligent transportation systems, healthcare industry and so on.